South America cruises with Orbitz offer the utmost in vacation fun and leisure, from one end of the continent to the other.
Set sail to the west coast city of Cartagena, Columbia, and experience the thrill of walking through the old, Spanish-colonial streets of downtown, immersed with authentic restaurants, shops and exquisite architecture. Colon, Panama offers an incredible shot of the Panama Canal, a 48-mile waterway which connects the Pacific and Atlantic Oceans. Arica, Chile is a port stationed on the Pacific coast and known for its beautiful and radiant beaches.
To the far east of South America, we’ll take you to the breathtaking beaches of Santos (Sao Paulo) or Ilhabela, the “Salt Capital” of Brazil. Discover the ancient artifacts and shipwrecked vessels resting at the bottom of the sea, just off the coast. For a more lively experience, visit Buzios and get down with their vivacious nightlife which includes discos, nightclubs and dynamic restaurants.
Don’t forget the beauty and charm of the country of Uruguay, a haven for spectacular cruise ports like Punta del Este and Montevideo; both exhibit extraordinary beaches, incredible surf and, on shore, a multitude of fun and exuberant tourist activities.
Book your South America cruise adventure with Orbitz, and you’re sure to take home memories of a vacation experience you will never forget.
Terms & Conditions
Total cruise prices listed are samples in U.S. dollars of select stateroom category types as indicated and include non-commissionable fares. All prices and bonus offers are valid only for new individual bookings for select stateroom categories on select sailings aboard select cruise lines. Total cruise prices include government taxes and fees, airfare, and a non-refundable $24.99 processing fee per booking. Minimum hotel costs apply as follows: $250 for the $75 promo code, $300 for the $100 promo code, $400 for the $150 promo code, $475 for the $200 promo code, $550 for the $300 promo code, and $750 for the $500 promo code, $1,000 for the $750 hotel promo code and $1,250 for the $1,000 hotel promo code. Cancellation penalties, blackout dates, and other restrictions may apply. Total cruise prices and bonus offers vary by departure date and city, sailing, ship, and stateroom category selected and are subject to availability, capacity-controlled, limited by each cruise line, may not be combinable with other offers, and may be changed or withdrawn at any time without notice. All reservations must be made in U.S. dollars; restrictions may apply for non-U.S. residents. Full Terms & Conditions. Best Price Guarantee restrictions and instructions apply; see our Best Rate Guarantee Policy.
If you or a guest is pregnant or traveling with an infant child, or if there is a need to communicate a request for special meals, medical conditions or physical challenges, we ask that you please call 888-656-8184. Cruise Specialists are available 24 hours a day, 7 days a week. We will do everything we can to meet your needs and answer all of your questions.
Minimum age requirements may apply.
Book an eligible stateroom on any qualifying sailing and receive a free upgrade! In some cases, you'll be upgraded to a more desirable location aboard your ship. In other instances, you'll be upgraded to a stateroom with extra space and/or a better view. It's also possible that you might receive all of these benefits. Select your sailing date to see which upgrades are available.