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Treat Yourself to a Fantastic South America Cruise

Experience the Pleasures of a South America Cruise

South America cruises with Orbitz offer the utmost in vacation fun and leisure, from one end of the continent to the other.

Set sail to the west coast city of Cartagena, Columbia, and experience the thrill of walking through the old, Spanish-colonial streets of downtown, immersed with authentic restaurants, shops and exquisite architecture. Colon, Panama offers an incredible shot of the Panama Canal, a 48-mile waterway which connects the Pacific and Atlantic Oceans. Arica, Chile is a port stationed on the Pacific coast and known for its beautiful and radiant beaches.

To the far east of South America, we’ll take you to the breathtaking beaches of Santos (Sao Paulo) or Ilhabela, the “Salt Capital” of Brazil. Discover the ancient artifacts and shipwrecked vessels resting at the bottom of the sea, just off the coast. For a more lively experience, visit Buzios and get down with their vivacious nightlife which includes discos, nightclubs and dynamic restaurants.

Don’t forget the beauty and charm of the country of Uruguay, a haven for spectacular cruise ports like Punta del Este and Montevideo; both exhibit extraordinary beaches, incredible surf and, on shore, a multitude of fun and exuberant tourist activities.

Book your South America cruise adventure with Orbitz, and you’re sure to take home memories of a vacation experience you will never forget.

Home > Cruise Destinations > South America
South America Cruises
Spring Savings Event
Savings on all fleets, up to $1,000 hotel promo code + more!

SOUTH AMERICA CRUISE DEALS
SOUTH AMERICA CRUISE DEALS
Royal Caribbean
Rhapsody of the Seas, Santos, Brazil
Customer Reviews: 1 Smile 1 Smile 1 Smile .5 Smiles 0 Smiles
Interior Oceanview Balcony Suite
$974 $1,131 $1,454 $1,649
Celebrity Cruises
Celebrity Infinity, Ft. Lauderdale, Florida
Customer Reviews: 1 Smile 1 Smile 1 Smile .5 Smiles 0 Smiles
Interior Oceanview Balcony Suite
$1,149 $1,369 $2,079 $3,549
Brochure price $2,739. Save up to 56% off brochure price!
Holland America Line
Zaandam, Buenos Aires, Argentina
Customer Reviews: 1 Smile 1 Smile 1 Smile .5 Smiles 0 Smiles
Interior Oceanview Balcony Suite
$1,199 $1,399 $2,599 $4,999
Princess Cruises
Star Princess, San Pedro, California
Customer Reviews: 1 Smile 1 Smile 1 Smile .5 Smiles 0 Smiles
Interior Oceanview Balcony Suite
$1,299 $1,399 $1,899 $2,199
Brochure price $2,849. Save up to 54% off brochure price!
Holland America Line
Zaandam, Valparaiso, Chile
Customer Reviews: 1 Smile 1 Smile 1 Smile .5 Smiles 0 Smiles
Interior Oceanview Balcony Suite
$1,299 $1,499 $2,599 $4,999
Brochure price $3,399. Save up to 59% off brochure price!
Norwegian Cruise Line
Norwegian Sun, Buenos Aires, Argentina
Customer Reviews: 1 Smile 1 Smile 1 Smile .5 Smiles 0 Smiles
Interior Oceanview Balcony Suite
$1,399 $1,689 $2,309 $3,999
Brochure price $3,099. Save up to 53% off brochure price!
Norwegian Cruise Line
Norwegian Sun, Valparaiso, Chile
Customer Reviews: 1 Smile 1 Smile 1 Smile .5 Smiles 0 Smiles
Interior Oceanview Balcony Suite
$1,469 $1,849 $2,309 $4,159
Brochure price $3,199. Save up to 53% off brochure price!
Holland America Line
Amsterdam, Callao, Peru
Customer Reviews: 1 Smile 1 Smile 1 Smile .5 Smiles 0 Smiles
Interior Oceanview Balcony Suite
$1,499 $1,699 $2,999 $4,999
Royal Caribbean
Rhapsody of the Seas, Santos, Brazil
Customer Reviews: 1 Smile 1 Smile 1 Smile .5 Smiles 0 Smiles
Interior Oceanview Balcony Suite
$1,799 $2,459 $2,796 $3,126
Brochure price $3,599. Save up to 51% off brochure price!
Norwegian Cruise Line
Norwegian Sun, San Diego, California
Customer Reviews: 1 Smile 1 Smile 1 Smile .5 Smiles 0 Smiles
Interior Oceanview Balcony Suite
$1,749 $1,939 $2,909 $4,879
Princess Cruises
Star Princess, Valparaiso, Chile
Customer Reviews: 1 Smile 1 Smile 1 Smile .5 Smiles 0 Smiles
Interior Oceanview Balcony Suite
$1,998 $2,198 $2,798 $3,456
Brochure price $3,699. Save up to 51% off brochure price!
Holland America Line
Zaandam, San Diego, California
Customer Reviews: 1 Smile 1 Smile 1 Smile .5 Smiles 0 Smiles
Interior Oceanview Balcony Suite
$1,799 $1,999 $3,399 $6,899
Brochure price $8,198. Save up to 73% off brochure price!
Oceania Cruises
Marina, Rio De Janeiro, Brazil
Customer Reviews: 1 Smile 1 Smile 1 Smile .5 Smiles 0 Smiles
Interior Oceanview Balcony Suite
$2,199 $2,999 $3,599 $5,299
Brochure price $15,990. Save up to 59% off brochure price!
Crystal Cruises
Crystal Symphony, San Juan, Puerto Rico
Customer Reviews: 1 Smile 1 Smile 1 Smile 1 Smile .5 Smiles
Interior Oceanview Balcony Suite
N/A $6,495 $9,765 $23,250
Brochure price $29,598. Save up to 61% off brochure price!
Regent Seven Seas Cruises
Seven Seas Navigator, Miami, Florida
Customer Reviews: 1 Smile 1 Smile 1 Smile 1 Smile 0 Smiles
Interior Oceanview Balcony Suite
N/A N/A N/A $11,599

About South America
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Terms & Conditions
Total cruise prices listed are samples in U.S. dollars of select stateroom category types as indicated and include non-commissionable fares. All prices and bonus offers are valid only for new individual bookings for select stateroom categories on select sailings aboard select cruise lines. Total cruise prices include government taxes and fees, airfare, and a non-refundable $24.99 processing fee per booking. Minimum hotel costs apply as follows: $250 for the $75 promo code, $300 for the $100 promo code, $400 for the $150 promo code, $475 for the $200 promo code, $550 for the $300 promo code, and $750 for the $500 promo code, $1,000 for the $750 hotel promo code and $1,250 for the $1,000 hotel promo code. Cancellation penalties, blackout dates, and other restrictions may apply. Total cruise prices and bonus offers vary by departure date and city, sailing, ship, and stateroom category selected and are subject to availability, capacity-controlled, limited by each cruise line, may not be combinable with other offers, and may be changed or withdrawn at any time without notice. All reservations must be made in U.S. dollars; restrictions may apply for non-U.S. residents. Full Terms & Conditions. Best Price Guarantee restrictions and instructions apply; see our Best Rate Guarantee Policy.

Special requirements
If you or a guest is pregnant or traveling with an infant child, or if there is a need to communicate a request for special meals, medical conditions or physical challenges, we ask that you please call 888-656-8184. Cruise Specialists are available 24 hours a day, 7 days a week. We will do everything we can to meet your needs and answer all of your questions.

Minimum age requirements may apply.

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