Treat Yourself to a Fantastic South America Cruise

Experience the Pleasures of a South America Cruise

South America cruises with Orbitz offer the utmost in vacation fun and leisure, from one end of the continent to the other.

Set sail to the west coast city of Cartagena, Columbia, and experience the thrill of walking through the old, Spanish-colonial streets of downtown, immersed with authentic restaurants, shops and exquisite architecture. Colon, Panama offers an incredible shot of the Panama Canal, a 48-mile waterway which connects the Pacific and Atlantic Oceans. Arica, Chile is a port stationed on the Pacific coast and known for its beautiful and radiant beaches.

To the far east of South America, we’ll take you to the breathtaking beaches of Santos (Sao Paulo) or Ilhabela, the “Salt Capital” of Brazil. Discover the ancient artifacts and shipwrecked vessels resting at the bottom of the sea, just off the coast. For a more lively experience, visit Buzios and get down with their vivacious nightlife which includes discos, nightclubs and dynamic restaurants.

Don’t forget the beauty and charm of the country of Uruguay, a haven for spectacular cruise ports like Punta del Este and Montevideo; both exhibit extraordinary beaches, incredible surf and, on shore, a multitude of fun and exuberant tourist activities.

Book your South America cruise adventure with Orbitz, and you’re sure to take home memories of a vacation experience you will never forget.

SOUTH AMERICA CRUISE DEALS

SOUTH AMERICA CRUISE DEALS

Brochure price $2,622 – Save up to 89%
3.5 / 5  (1,175 reviews)

Norwegian Sun

Departing from: Buenos Aires, Argentina
Ports of Call: Buenos Aires, Argentina • Montevideo, Uruguay • Punta Del Este, Uruguay • Santos (Sao Paulo), Brazil • Ilha Grande, Brazil • Rio De Janeiro, Brazil
interior from
$299
$43/night
oceanview from
$299
$43/night
balcony from
$399
$57/night
suite from
$1,599
$228/night
Bonus Offers Available:
  • FREE at Sea: Get up to 4 FREE Offers
  • FREE at Sea: Get up to 4 FREE Offers
    Book a studio or inside stateroom category and you can choose between an Ultimate Beverage package for 2, a Specialty Dining package, a 250 minute internet package or $50 per port shore excursion credit. Book an oceanview, balcony or mini-suite category stateroom and you can choose two of the amenities. Can't decide which amenities you want book a Haven Suite stateroom category and receive all four of the amenities. This offer is for new reservations only. NOT VALID FOR ALL FARES DISPLAYING ONLINE AND IS RESTRICTED TO CERTAIN FARE CODES. Not valid for categories IX, OX, BX or MX.
  • Up To $1000 Onboard Credit!
  • Up To $1000 Onboard Credit!
    EXCLUSIVE: Up to $1000 to spend onboard your ship on spa treatments, shops, specialty restaurants, beverage packages, shore excursions, etc. Actual amounts vary based on your net cruise fare, minus taxes and port charges. Call us today!
  • Earn Unlimited Future Cruise Credits for Referrals!
  • Earn Unlimited Future Cruise Credits for Referrals!
    Each time you refer a new customer to us, we will give you a $50 Future Cruise Credit after their sailing departs. There is no limit to the number of Future Cruise Credits earned, and you can apply them toward your next booking with us. Simply have your referral call us to book, indicate that you recommended us, and provide us with your name and city/state or email address. Offer is not valid if the referred customer is traveling aboard the same sailing as you.
Brochure price $9,299 – Save up to 56%
3.8 / 5  (249 reviews)

Zaandam

Departing from: Buenos Aires, Argentina
Ports of Call: Buenos Aires, Argentina • Montevideo, Uruguay • Port Stanley, Falkland Islands • Cruise Strait Of Magellan • Punta Arenas, Chile • Cruise Cockburn Channel • Cruise Beagle Channel • Cruise Glacier Alley • Ushuaia, Tierra Del Fuego, Argentina • Cruise Cape Horn • Cruise Canal Sarmiento • Cruise Chilean Fjords • Puerto Montt, Chile • Valparaiso (Santiago), Chile
interior from
Call
oceanview from
Call
balcony from
$4,049
$289/night
suite from
$5,169
$369/night
Bonus Offers Available:
  • Up To $1000 Onboard Credit!
  • Up To $1000 Onboard Credit!
    EXCLUSIVE: Up to $1000 to spend onboard your ship on spa treatments, shops, specialty restaurants, beverage packages, shore excursions, etc. Actual amounts vary based on your net cruise fare, minus taxes and port charges. Call us today!
  • CALL: Up to $100 FREE Onboard Spending!
  • CALL: Up to $100 FREE Onboard Spending!
    Call to book any stateroom on a qualifying Holland America sailing departing between 1/3/17 and 11/29/17, and we will give you up to $100 FREE onboard spending; amount varies by sailing! Hurry - limited space available.
  • Earn Unlimited Future Cruise Credits for Referrals!
  • Earn Unlimited Future Cruise Credits for Referrals!
    Each time you refer a new customer to us, we will give you a $50 Future Cruise Credit after their sailing departs. There is no limit to the number of Future Cruise Credits earned, and you can apply them toward your next booking with us. Simply have your referral call us to book, indicate that you recommended us, and provide us with your name and city/state or email address. Offer is not valid if the referred customer is traveling aboard the same sailing as you.
3.8 / 5  (476 reviews)

Celebrity Infinity

Departing from: Valparaiso (Santiago), Chile
Ports of Call: Valparaiso (Santiago), Chile • Arica, Chile • Callao (Lima), Peru • Manta, Ecuador • Panama Canal Full Transit • Colon, Panama • Cartagena, Colombia • Miami, Florida
interior from
Call
oceanview from
$2,499
$179/night
balcony from
$2,699
$193/night
suite from
$3,749
$268/night
Bonus Offers Available:
  • Up To $1000 Onboard Credit!
  • Up To $1000 Onboard Credit!
    EXCLUSIVE: Up to $1000 to spend onboard your ship on spa treatments, shops, specialty restaurants, beverage packages, shore excursions, etc. Actual amounts vary based on your net cruise fare, minus taxes and port charges. Call us today!
  • Earn Unlimited Future Cruise Credits for Referrals!
  • Earn Unlimited Future Cruise Credits for Referrals!
    Each time you refer a new customer to us, we will give you a $50 Future Cruise Credit after their sailing departs. There is no limit to the number of Future Cruise Credits earned, and you can apply them toward your next booking with us. Simply have your referral call us to book, indicate that you recommended us, and provide us with your name and city/state or email address. Offer is not valid if the referred customer is traveling aboard the same sailing as you.
2.9 / 5  (28 reviews)

MSC Preziosa

Departing from: Santos (Sao Paulo), Brazil
Ports of Call: Santos (Sao Paulo), Brazil • Rio De Janeiro, Brazil • Salvador De Bahia, Brazil • Ilheus, Brazil • Buzios, Brazil • Santos (Sao Paulo), Brazil
interior from
Call
oceanview from
$1,289
$184/night
balcony from
$1,539
$220/night
suite from
Call
Bonus Offers Available:
  • Earn Unlimited Future Cruise Credits for Referrals!
  • Earn Unlimited Future Cruise Credits for Referrals!
    Each time you refer a new customer to us, we will give you a $50 Future Cruise Credit after their sailing departs. There is no limit to the number of Future Cruise Credits earned, and you can apply them toward your next booking with us. Simply have your referral call us to book, indicate that you recommended us, and provide us with your name and city/state or email address. Offer is not valid if the referred customer is traveling aboard the same sailing as you.
3.8 / 5  (476 reviews)

Celebrity Infinity

Departing from: Buenos Aires, Argentina
Ports of Call: Buenos Aires, Argentina • Montevideo, Uruguay • Punta Del Este, Uruguay • Puerto Madryn, Argentina • Cruise Cape Horn • Ushuaia, Tierra Del Fuego, Argentina • Punta Arenas, Chile • Cruise Strait Of Magellan • Cruise Chilean Fjords • Puerto Montt, Chile • Valparaiso (Santiago), Chile
interior from
Call
oceanview from
Call
balcony from
$2,299
$164/night
suite from
Call
Bonus Offers Available:
  • Go Better: Choose 2 FREE Perks!
  • Go Better: Choose 2 FREE Perks!
    Customize your cruise vacation and select the amenities you desire. Select GO BETTER - book an oceanview or higher category on select Celebrity Cruise sailings and choose 2 of the 4 amenities: Free pre-paid gratuities for 2, Classic Beverage Package for 2, up to $300 onboard spending or unlimited onboard internet! New bookings only, not all fares displaying online qualify, other restrictions may apply.
  • GO BEST- Ask how you can get more perks!
  • GO BEST- Ask how you can get more perks!
    Ask how you can get all 4 perks! Upgrade to GO BEST & you can receive all of the following amenities: Free pre-paid gratuities for 2, Classic Beverage Package for 2, up to $300 onboard spending AND unlimited onboard internet! It will even upgrade your Beverage Package to Premium! New bookings only, additional surcharges apply, not all staterooms, fares or departures qualify; other restrictions may apply.
  • Sail Beyond Sale: Save Up to $800 Per Stateroom
  • Sail Beyond Sale: Save Up to $800 Per Stateroom
    Book a stateroom on select Celebrity Cruise sailings departing 2/1/17 - 4/30/18 and receive up to a $800 instant savings per stateroom. Pricing shown reflects savings. Offer not valid for singles; port taxes and government fees are at full price; new bookings only; additional restrictions may apply. Hurry - offer ends 11:59 pm EST on 2/28/17!
  • Earn Unlimited Future Cruise Credits for Referrals!
  • Earn Unlimited Future Cruise Credits for Referrals!
    Each time you refer a new customer to us, we will give you a $50 Future Cruise Credit after their sailing departs. There is no limit to the number of Future Cruise Credits earned, and you can apply them toward your next booking with us. Simply have your referral call us to book, indicate that you recommended us, and provide us with your name and city/state or email address. Offer is not valid if the referred customer is traveling aboard the same sailing as you.
2.9 / 5  (28 reviews)

MSC Preziosa

Departing from: Santos (Sao Paulo), Brazil
Ports of Call: Santos (Sao Paulo), Brazil • Rio De Janeiro, Brazil • Salvador De Bahia, Brazil • Buzios, Brazil • Santos (Sao Paulo), Brazil
interior from
$1,599
$228/night
oceanview from
Call
balcony from
Call
suite from
Call
Bonus Offers Available:
  • Earn Unlimited Future Cruise Credits for Referrals!
  • Earn Unlimited Future Cruise Credits for Referrals!
    Each time you refer a new customer to us, we will give you a $50 Future Cruise Credit after their sailing departs. There is no limit to the number of Future Cruise Credits earned, and you can apply them toward your next booking with us. Simply have your referral call us to book, indicate that you recommended us, and provide us with your name and city/state or email address. Offer is not valid if the referred customer is traveling aboard the same sailing as you.
Brochure price $5,099 – Save up to 80%
3.8 / 5  (249 reviews)

Zaandam

Departing from: Valparaiso (Santiago), Chile
Ports of Call: Valparaiso (Santiago), Chile • Coquimbo (La Serena), Chile • General San Martin (Pisco), Peru • Callao (Lima), Peru • Salaverry (Trujillo), Peru • Manta, Ecuador • Puerto Caldera (Puntarenas), Costa Rica • Puerto Chiapas (Tapachula), Mexico • Cabo San Lucas, Mexico • San Diego, California
interior from
$999
$56/night
oceanview from
$1,099
$61/night
balcony from
$2,799
$156/night
suite from
$6,899
$383/night
Bonus Offers Available:
  • Limited Time Reduced Rates!
  • Limited Time Reduced Rates!
    Limited time reduced rates - hurry these rates won't last long! This offer is valid for new reservations only, certain restrictions may apply. This rate is non-refundable and not combinable with other cruise line promotions.
  • Free Upgrades, Onboard Spending and more!
  • Free Upgrades, Onboard Spending and more!
    Book your cruise vacation on a select 2017-2018 Holland America sailing and you can receive free stateroom upgrades and up to $500 FREE onboard spending. Book a suite and also receive free prepaid gratuities. Onboard spending amount is based on length of sailing and category purchased. Restrictions apply - new bookings only, subject to availability.
  • Up To $1000 Onboard Credit!
  • Up To $1000 Onboard Credit!
    EXCLUSIVE: Up to $1000 to spend onboard your ship on spa treatments, shops, specialty restaurants, beverage packages, shore excursions, etc. Actual amounts vary based on your net cruise fare, minus taxes and port charges. Call us today!
  • CALL: Up to $100 FREE Onboard Spending!
  • CALL: Up to $100 FREE Onboard Spending!
    Call to book any stateroom on a qualifying Holland America sailing departing between 1/3/17 and 11/29/17, and we will give you up to $100 FREE onboard spending; amount varies by sailing! Hurry - limited space available.
  • Earn Unlimited Future Cruise Credits for Referrals!
  • Earn Unlimited Future Cruise Credits for Referrals!
    Each time you refer a new customer to us, we will give you a $50 Future Cruise Credit after their sailing departs. There is no limit to the number of Future Cruise Credits earned, and you can apply them toward your next booking with us. Simply have your referral call us to book, indicate that you recommended us, and provide us with your name and city/state or email address. Offer is not valid if the referred customer is traveling aboard the same sailing as you.
About South America
 
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Terms & Conditions
Total cruise prices listed are samples in U.S. dollars of select stateroom category types as indicated and include non-commissionable fares. All prices and bonus offers are valid only for new individual bookings for select stateroom categories on select sailings aboard select cruise lines. Total cruise prices include government taxes and fees, airfare, and a non-refundable $24.99 processing fee per booking. Minimum hotel costs apply as follows: $250 for the $75 promo code, $300 for the $100 promo code, $400 for the $150 promo code, $475 for the $200 promo code, $550 for the $300 promo code, and $750 for the $500 promo code, $1,000 for the $750 hotel promo code and $1,250 for the $1,000 hotel promo code. Cancellation penalties, blackout dates, and other restrictions may apply. Total cruise prices and bonus offers vary by departure date and city, sailing, ship, and stateroom category selected and are subject to availability, capacity-controlled, limited by each cruise line, may not be combinable with other offers, and may be changed or withdrawn at any time without notice. All reservations must be made in U.S. dollars; restrictions may apply for non-U.S. residents. Full Terms & Conditions. Best Price Guarantee restrictions and instructions apply; see our Best Rate Guarantee Policy.

Special requirements
If you or a guest is pregnant or traveling with an infant child, or if there is a need to communicate a request for special meals, medical conditions or physical challenges, we ask that you please call 888-656-8184. Cruise Specialists are available 24 hours a day, 7 days a week. We will do everything we can to meet your needs and answer all of your questions.

Minimum age requirements may apply.
Free upgrade!

Book an eligible stateroom on any qualifying sailing and receive a free upgrade! In some cases, you'll be upgraded to a more desirable location aboard your ship. In other instances, you'll be upgraded to a stateroom with extra space and/or a better view. It's also possible that you might receive all of these benefits. Select your sailing date to see which upgrades are available.

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